MEDIX, God. 28 Br. 153/154  •  Pregledni članak  •  Gastroenterologija HR ENG

Whippleova bolest: crijevna upala i pomalo zaboravljeni klinički entitetWhipple’s disease: intestinal inflammation and a somewhat forgotten clinical entity

Biljana Knežević, Sanda Mustapić, Duško Kardum, Marko Banić

Whippleova bolest rijetka je, sustavna infektivna bolest koju uzrokuje bakterija Tropheryma whipplei. Bolest najčešće pogađa sredovječne muškarce bijele rase. Klinički se očituje artralgijama, proljevom, abdominalnim bolovima i gubitkom tjelesne mase. Whippleova bolest primarno zahvaća tanko crijevo, no istodobno mogu biti zahvaćeni i drugi organski sustavi. Dijagnoza se najčešće postavlja uzimanjem biopsija tankoga crijeva, a liječenje uključuje primjenu antibiotika. Neliječena bolest može imati fatalni tijek

Ključne riječi:
gastrointestinalni simptomi; Tropheryma whipplei; Whippleova bolest

Članak u cijelosti pročitajte u tiskanom izdanju MEDIX, God. 28 Br. 153/154

Whipple’s disease is a rare systemic infectious disease caused by the bacterium Tropheryma whipplei which affects mostly middle-aged white men. Patients present with arthralgia, diarrhea, abdominal pain and weight loss. Whipple’s disease primarily affects the small intestine, but several organs can simultaneously be involved. The disease is commonly diagnosed by small-bowel biopsy, treatment includes the use of antibiotics. An untreated disease can have a fatal course

Key words:
gastrointestinal symptoms; Tropheryma whipplei; Whipple’s disease